A running roundup of business openings, closings, and notable local-economy developments in and around Kirksville. Entries are drawn from local news coverage, the Chamber of Commerce, and Main Street Kirksville — with source links so you can read the original reporting.
Sourced from KTVO (the regional news outlet serving northeast Missouri), Hoodline, Main Street Kirksville, and the Kirksville Area Chamber of Commerce. This repository does not independently report on individual businesses — it aggregates and links to public reporting and official announcements. Have a correction or an item to add? Nothing on this page is exhaustive; check the source links for the fullest picture.
Recent Openings & Expansions
7 Brew Coffee — new drive-thru stand
Opening fall 2026 · 2206 N. Baltimore St. (Walmart Supercenter outparcel)
A 510-sq-ft modular drive-thru coffee stand, craned into place in one day, is set to open outside the Kirksville Walmart. The Arkansas-based chain’s local franchise group, Brew Crew LLC, says the location will bring about 80 local jobs; hiring is underway.
Main Street Kirksville — downtown investment
Ongoing · Downtown Kirksville Square
Main Street Kirksville, the nonprofit downtown-revitalization group, received a 2026 AARP Community Challenge grant and has been running an “Adopt-a-Pot” sponsorship program for downtown planters alongside a new mural project on the Pickell Abstract building — part of a broader push to keep downtown storefronts active and attractive to new tenants.
Recent Closings & Transitions
Hollister Incorporated — Kirksville plant
Closure by end of 2025 · Medical/ostomy products manufacturing
Hollister announced it is transitioning ostomy-product production from its Kirksville plant, open since 1965, to other company facilities. Layoffs began in March 2025 with the transition running through the year; UAW Local 710 represents affected workers.
Westlake Ace Hardware — Kirksville
Closed for good, October 2025
A longtime Kirksville hardware retailer announced it would close permanently in October 2025, per KTVO reporting.
King Appliance and Furniture
116 N. Franklin St. · Retirement closure
Longtime downtown retailer running a “Retirement Sale” with closure confirmed, per KTVO reporting; no firm closing date specified.
Sieren’s Palace
108 W. Harrison St. · Owner seeking sale or closure
Owner Herb Sieren has been seeking to sell the business; if a buyer isn’t found, per KTVO reporting the plan is a full closure. Status should be confirmed directly with the business before relying on this for current hours.
Business Resources
Kirksville Area Chamber of Commerce
Local business directory, events, ribbon cuttings
City of Kirksville — Start / Register a Business
Permits, licensing, “I’m Open, Now What?” guide
